Gut leakage markers in response to strenuous exercise in patients with suspected coronary artery disease

Abstract Introduction Although regular physical activity is associated with reduced risk of cardiovascular disease (CVD), acute vigorous exercise seems to transiently increase the coronary events in patients underlying CVD. Some studies have reported associate microbial diversity, whereas elevated levels gut leakage markers been shown after strenuous healthy individuals. Any predictive value a temporary on susceptible individuals unknown. Purpose We aimed explore response bout symptoms chronic syndrome (CCS). hypothesized that would exercise, and be higher angiographically verified CAD. Methods Patients referred stress testing or angiography due suggestive CCS were included (n=327). A maximal ECG test was performed using bicycle ergometer. Venous blood samples drawn at rest prior within 5 min ended, for analysis soluble cluster differentiation 14 (sCD14), lipopolysaccharide-binding protein (LBP) intestinal fatty-acid binding (I-FABP) by ELISAs. Quantification lipopolysaccharide (LPS) relative quantification gene expression toll-like receptor 4 (TLR4) circulating leukocytes subset (n=101). then underwent angiography, grouped according degree Results Of 287 who completed 69 (24%) had no CAD, 88 (31%) non-significant CAD 130 (45%) significant Mean duration 10:05±4:46 did not differ between groups. There differences resting In total population, sCD14, LBP LPS increased significantly (p<0.0001, all), I-FABP not. The TLR4 decreased (p<0.0001). exercise-induced changes any measured groups Conclusion CCS, LPS, sCD14 suggesting even short bouts are leakage. decrease may discussed compensatory possibly reflecting an translation LPS. presence seem impact markers. FUNDunding Acknowledgement Type funding sources: Foundation. Main source(s): Stein Erik Hagen Foundation Clinical Heart Research, Olso, Norway